Stable tissue-simulating phantoms with various water and lipid contents for diffuse optical spectroscopy

Biomed Opt Express. 2018 Oct 29;9(11):5792-5808. doi: 10.1364/BOE.9.005792. eCollection 2018 Nov 1.


We introduced a method for producing solid phantoms with various water-to-lipid ratios that can simulate the absorption, and to some extent the scattering characteristics of human breast tissue. We also achieved phantom stability for a minimum of one month by solidifying the emulsion phantoms. The characteristics of the phantoms were evaluated using the six-wavelength time-domain diffuse optical spectroscopy (TD-DOS) system we developed to measure water and lipid contents and hemoglobin concentration. The TD-DOS measurements were validated with a magnetic resonance imaging system.