Late-Onset Nevus Comedonicus With Follicular Epidermolytic Hyperkeratosis-Case Report and Review of the Literature

Am J Dermatopathol. 2019 Jun;41(6):453-455. doi: 10.1097/DAD.0000000000001317.


Nevus comedonicus is a rare cutaneous follicular hamartoma, characterized by the clustering of papules with firm, blackened horny buffers. It is usually present at birth or during childhood, although few cases of late-onset disease have been described. We present a case of postmenopausal-onset nevus comedonicus in a 55-year-old white woman without relevant medical history. Skin biopsy showed the typical features of several cyst-dilated follicular structures occupied by keratotic material and the peculiar finding of epidermolytic hyperkeratosis of the follicular epithelial walls. A brief review of the clinical and histological features of other similar cases published in the literature is performed.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Female
  • Hamartoma / pathology*
  • Humans
  • Hyperkeratosis, Epidermolytic / pathology*
  • Middle Aged
  • Skin Diseases / pathology*