Objective: To analyze and reveal the distribution, research hotspots and study trend of worldwide published articles correlated with HIV/AIDS post-exposure prophylaxis (PEP), and provide information for related studies in China. Methods: CiteSpace software 5.1 was used to visualize all related papers in the web of science database published during 2000-2017. Results: The average growth rate of international PEP-related papers was 10.78%,and number of published papers in 2016 was highest (n=34), relevant research hotspots have shifted from the prevention of occupational HIV exposure to the prevention of non-occupational HIV exposure in group at high risk, such as MSM, in recent years. Clustering analysis classified research hotspots into three categories, including risk reduction through enhanced intervention, current status of global HIV PEP and German-Austrian Recommendation. Conclusions: Non-occupational HIV PEP in groups at high-risk, especially MSM, has received increasing attention in recent years, the research of PEP mainly focus on improving the awareness and use of PEP in MSM and compliance in the course of medication. In the context of severe HIV epidemic in MSM without effective control in China, PEP should be strengthened to assess and explore the risk of HIV infection in MSM to provide reference for medical personnel and related departments to implement HIV non-occupation exposure blockade and formulate PEP medication.
目的： 从文献计量分析角度对国际HIV暴露后预防（post-exposure prophylaxis，PEP）的发文量、研究热点及其变化趋势等方面进行分析和研究，旨在为我国相关研究开展及防治条例制订提供参考依据。 方法： 利用CiteSpace 5.1软件对Web of Science核心合集数据库收录的2000－2017年间所有PEP相关文献进行可视化分析。 结果： 国际上PEP相关研究发文量平均增速为10.78%，2016年发文量达到顶峰（34篇），近年相关研究热点从预防HIV职业暴露向MSM等高危人群的HIV非职业暴露后阻断转移，聚类分析显示PEP研究热点主要集中于强化干预减少HIV感染风险、全球HIV PEP的形势、德国-奥地利预防指南3个领域。 结论： 近年高危人群尤其MSM人群的HIV非职业暴露后预防日益受到国际关注，相关研究主要集中于提高PEP在MSM人群中的知晓和使用度以及服药过程中的依从性等方面。在我国MSM人群HIV疫情较为严峻且未得到有效控制的背景下应加强PEP对MSM人群HIV感染风险的评估和探索，以便为医务人员实施HIV非职业暴露阻断及相关部门制定PEP用药指南提供参考依据。.
Keywords: Clustering analysis; Frontier evolution; HIV post-exposure prophylaxis; Visual analysis.