Monocyte-Derived Macrophages: The Missing Link in Organ Transplantation

Immunity. 2018 Nov 20;49(5):783-785. doi: 10.1016/j.immuni.2018.11.005.

Abstract

Successful organ transplantation requires an optimal innate immune response to avoid tissue injury. In this issue of Immunity, Braza et al. (2018) inhibit pro-inflammatory activation of infiltrating graft macrophages using nanotechnology tools to promote immune tolerance, leading to long-term transplant acceptance in mouse models.

Publication types

  • Comment

MeSH terms

  • Animals
  • Graft Rejection*
  • Immunity, Innate
  • Inflammation
  • Macrophages
  • Mice
  • Myeloid Cells
  • Organ Transplantation*