Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules

Rick M Maizels; Hermelijn H Smits; Henry J McSorley

doi:10.1016/j.immuni.2018.10.016

Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules

Immunity. 2018 Nov 20;49(5):801-818. doi: 10.1016/j.immuni.2018.10.016.

Authors

Rick M Maizels¹, Hermelijn H Smits², Henry J McSorley³

Affiliations

¹ Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK. Electronic address: rick.maizels@glasgow.ac.uk.
² Leiden University Medical Center, Leiden, the Netherlands. Electronic address: h.h.smits@lumc.nl.
³ Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK. Electronic address: henry.mcsorley@ed.ac.uk.

Abstract

Helminths are extraordinarily successful parasites due to their ability to modulate the host immune response. They have evolved a spectrum of immunomodulatory molecules that are now beginning to be defined, heralding a molecular revolution in parasite immunology. These discoveries have the potential both to transform our understanding of parasite adaptation to the host and to develop possible therapies for immune-mediated disease. In this review we will summarize the current state of the art in parasite immunomodulation and discuss perspectives on future areas for research and discovery.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adaptive Immunity
Animals
Biological Evolution
Dendritic Cells / immunology
Dendritic Cells / metabolism
Helminthiasis / immunology*
Helminthiasis / parasitology
Helminths / immunology*
Host-Parasite Interactions*
Humans
Immunity, Innate
Immunomodulation*
Macrophages / immunology
Macrophages / metabolism

Abstract

Publication types

MeSH terms

Grants and funding