Novel Roles for SUMOylation in Cellular Plasticity

Bruno Di Stefano; Konrad Hochedlinger

doi:10.1016/j.tcb.2018.10.001

Novel Roles for SUMOylation in Cellular Plasticity

Trends Cell Biol. 2018 Dec;28(12):971-973. doi: 10.1016/j.tcb.2018.10.001. Epub 2018 Oct 26.

Authors

Bruno Di Stefano¹, Konrad Hochedlinger²

Affiliations

¹ Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA; Cancer Center, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, 1350 Massachusetts Avenue, Cambridge, MA 02138, USA.
² Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA; Cancer Center, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, 1350 Massachusetts Avenue, Cambridge, MA 02138, USA. Electronic address: khochedlinger@mgh.harvard.edu.

Abstract

Cell fate transitions involve rapid changes in gene expression patterns, yet the role of post-translational modifications in these processes remains underexplored. A recent study identifies SUMOylation as a guardian of cell identity that acts during differentiation and reprogramming by reinforcing active enhancers and maintaining silenced heterochromatin in a context-specific manner.

Publication types

Comment

MeSH terms

Cell Differentiation
Cell Plasticity
Chromatin*
Protein Processing, Post-Translational
Sumoylation*

Substances

Chromatin

Abstract

Publication types

MeSH terms

Substances

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