Neurocognitive function of 10-year-old multiples born less than 28 weeks of gestational age

J Perinatol. 2019 Feb;39(2):237-247. doi: 10.1038/s41372-018-0273-x. Epub 2018 Nov 21.


Introduction: Few studies have examined the relationship between birth plurality and neurocognitive function among children born extremely preterm.

Study design: We compared rates of Z-scores ≤-2 on 18 tests of neurocognitive function and academic achievement at age 10 years in 245 children arising from twin pregnancies, 55 from triplet pregnancies, and 6 from a septuplet pregnancy to that of 568 singletons, all of whom were born before the 28th week of gestation.

Results: In total, 874 children were evaluated at the age of 10 years. After adjusting for confounders, children of multifetal pregnancies performed significantly better on one of six subtests of executive function than their singleton peers. Performance was similar on all other assessments of intelligence, language, academic achievement, processing speed, visual perception, and fine motor skills.

Conclusion: We found no evidence that children born of multifetal pregnancies had worse scores than their singleton peers on assessments of neurocognitive and academic function.

Publication types

  • Multicenter Study
  • Observational Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Child
  • Cognition Disorders*
  • Educational Status
  • Executive Function*
  • Female
  • Gestational Age
  • Humans
  • Infant, Extremely Premature / psychology*
  • Intelligence
  • Language Development Disorders*
  • Logistic Models
  • Male
  • Motor Skills Disorders*
  • Pregnancy
  • Pregnancy, Multiple*
  • Pregnancy, Twin
  • Prospective Studies
  • Psychological Tests
  • United States
  • Visual Perception