Amniotic-Derived Treatments and Formulations

Clin Sports Med. 2019 Jan;38(1):45-59. doi: 10.1016/j.csm.2018.08.002.


In orthopedic sports medicine, amniotic-derived products have demonstrated promising preclinical and early clinical results for the treatment of tendon/ligament injuries, cartilage defects, and osteoarthritis. The amniotic membrane is a metabolically active tissue that has demonstrated anti-inflammatory, antimicrobial, antifibrotic, and epithelialization-promoting features that make it uniquely suited for several clinical applications. Although the existing clinical literature is limited, there are several ongoing clinical trials aiming to elucidate the specific applications and benefits of these products. This article reviews the current amniotic-derived treatment options and the existing literature on outcomes, complications, and safety profile of these products for use in sports medicine.

Keywords: Allograft; Amniotic fluid; Amniotic membrane; Sports medicine injury; Tissue regeneration.

Publication types

  • Review

MeSH terms

  • Amnion*
  • Animals
  • Cartilage Diseases / therapy*
  • Humans
  • Osteoarthritis / therapy*
  • Randomized Controlled Trials as Topic
  • Sports Medicine / trends*
  • Tendon Injuries / therapy*