Determinants of Myocardial Strain in Experimental Chronic Myocardial Infarction

Ultrasound Med Biol. 2019 Feb;45(2):568-578. doi: 10.1016/j.ultrasmedbio.2018.10.005. Epub 2018 Nov 19.


We evaluated the relationships between regional myocardial strain measured by speckle tracking echocardiography and viability, fibrosis, hypertrophy and oxygen consumption in the infarcted or remote myocardium in a pig model of chronic myocardial infarction (MI). Thirteen farm pigs with surgical occlusion of the left anterior descending coronary artery and five sham-operated pigs were studied 3 mo post-MI. Computed tomography revealed significant left ventricle remodeling. Reduced radial or circumferential strain identified areas of transmural infarction (area under the curve: 0.82 and 0.79, respectively). In the remote non-infarcted area, radial strain correlated inversely with the amount of fibrosis (r = -0.66, p = 0.04) and myocyte hypertrophy (r = -0.68, p = 0.03). Radial strain rate inversely correlated with myocardial resting oxygen consumption assessed with 11C-labeled acetate positron emission tomography (r = -0.71, p = 0.006). In conclusion, myocardial strain and strain rate reflect fibrosis, hypertrophy and oxygen consumption of the remote areas after MI.

Keywords: Cardiac computed tomography; Myocardial oxygen consumption; Myocardial perfusion; Positron emission tomography; Transthoracic echocardiography.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chronic Disease
  • Disease Models, Animal
  • Echocardiography / methods*
  • Heart / diagnostic imaging*
  • Heart / physiopathology*
  • Male
  • Myocardial Infarction / diagnostic imaging*
  • Myocardial Infarction / physiopathology*
  • Swine