Beneficial Effects of Resveratrol Administration-Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions

Nutrients. 2018 Nov 21;10(11):1813. doi: 10.3390/nu10111813.


Resveratrol (RV) is a natural non-flavonoid polyphenol and phytoalexin produced by a number of plants such as peanuts, grapes, red wine and berries. Numerous in vitro studies have shown promising results of resveratrol usage as antioxidant, antiplatelet or anti-inflammatory agent. Beneficial effects of resveratrol activity probably result from its ability to purify the body from ROS (reactive oxygen species), inhibition of COX (cyclooxygenase) and activation of many anti-inflammatory pathways. Administration of the polyphenol has a potential to slow down the development of CVD (cardiovascular disease) by influencing on certain risk factors such as development of diabetes or atherosclerosis. Resveratrol induced an increase in Sirtuin-1 level, which by disrupting the TLR4/NF-κB/STAT signal cascade (toll-like receptor 4/nuclear factor κ-light-chain enhancer of activated B cells/signal transducer and activator of transcription) reduces production of cytokines in activated microglia. Resveratrol caused an attenuation of macrophage/mast cell-derived pro-inflammatory factors such as PAF (platelet-activating factor), TNF-α (tumour necrosis factor-α and histamine. Endothelial and anti-oxidative effect of resveratrol may contribute to better outcomes in stroke management. By increasing BDNF (brain-derived neurotrophic factor) serum concentration and inducing NOS-3 (nitric oxide synthase-3) activity resveratrol may have possible therapeutical effects on cognitive impairments and dementias especially in those characterized by defective cerebrovascular blood flow.

Keywords: cardiovascular; cytokines; inflammation; pathways; resveratrol.

Publication types

  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases / drug therapy*
  • Cerebrovascular Circulation / drug effects
  • Cyclic AMP / genetics
  • Cyclic AMP / metabolism
  • Cyclooxygenase 1 / genetics
  • Cyclooxygenase 1 / metabolism
  • Cyclooxygenase Inhibitors / pharmacology
  • Cytokines / blood
  • Diabetes Mellitus / drug therapy
  • Disease Models, Animal
  • Humans
  • Inflammation / drug therapy
  • Platelet Aggregation Inhibitors / pharmacology
  • Polyphenols / pharmacology
  • Reactive Oxygen Species / metabolism
  • Resveratrol / pharmacology*
  • Sirtuin 1 / genetics
  • Sirtuin 1 / metabolism


  • Cyclooxygenase Inhibitors
  • Cytokines
  • Platelet Aggregation Inhibitors
  • Polyphenols
  • Reactive Oxygen Species
  • Cyclic AMP
  • Cyclooxygenase 1
  • PTGS1 protein, human
  • SIRT1 protein, human
  • Sirtuin 1
  • Resveratrol