Centriole Biogenesis: Symmetry Breaking and Site Selection

David P Ignacio; Valerie C Coffman; Adriana T Dawes

doi:10.1016/j.tcb.2018.11.001

Centriole Biogenesis: Symmetry Breaking and Site Selection

Trends Cell Biol. 2019 Jan;29(1):3-5. doi: 10.1016/j.tcb.2018.11.001. Epub 2018 Nov 21.

Authors

David P Ignacio¹, Valerie C Coffman², Adriana T Dawes³

Affiliations

¹ Molecular, Cellular and Developmental Biology Graduate Program, The Ohio State University, Columbus, OH 43210, USA.
² Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA.
³ Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA; Department of Mathematics, The Ohio State University, Columbus, OH 43210, USA. Electronic address: dawes.33@math.ohio-state.edu.

PMID: 30470626
DOI: 10.1016/j.tcb.2018.11.001

Abstract

Centrioles must duplicate as cells progress through the cell cycle but it is unclear how the site of duplication is selected. A recent computational study demonstrates that two separate but interacting feedback mechanisms (autocatalytic activation and substrate depletion) are capable of selecting a single site for centriole biogenesis.

Keywords: PLK4; STIL; centrioles; centrosomes; mathematical model; symmetry breaking.

Publication types

Review

MeSH terms

Centrioles / metabolism*
Humans
Protein Serine-Threonine Kinases / antagonists & inhibitors
Protein Serine-Threonine Kinases / metabolism

Substances

PLK4 protein, human
Protein Serine-Threonine Kinases