Is it Possible to Significantly Modify Blood Pressure with a Combined Nutraceutical on Top of a Healthy Diet? The Results of a Pilot Clinical Trial

High Blood Press Cardiovasc Prev. 2018 Dec;25(4):401-405. doi: 10.1007/s40292-018-0289-5. Epub 2018 Nov 23.


Introduction: Beyond the well-known effects on blood pressure (BP) of the dietary approaches to stop hypertension (DASH) and the Mediterranean diets associated to a correct lifestyle, often a lifestyle change is not simple and can show only long-time results: in this sense, a possible support might be derived from the use of some anti-hypertensive supplements or nutraceuticals, which may provide a significant reduction in blood pressure.

Aim: We conducted a randomized, double-blind, placebo-controlled clinical trial in a group of 36 pre-hypertensive and first-degree hypertensive patients.

Methods: The treatment period with a mix of bioactive substances (BPLN®, containing a donor of nitric oxide, magnesium, and vitamins) or placebo was 16-week long and was preceded by 4 weeks of diet stabilization.

Results: At the end of the intervention, patients treated with the nutraceutical product showed a significant reduction of all morning pressure parameters and of evening systolic blood pressure, both versus the baseline and versus the group treated with placebo. These effects were maintained even after the first 16 weeks of treatment, confirming that the preliminary results were not due to simple changes in volume and do not lead to adaptation/tachyphylaxis. No patient complained of any side effects while taking the active treatment and placebo.

Conclusions: The tested nutraceutical composite reduces systolic and diastolic blood pressure in the medium term, leading to a significant reduction in the estimated cardiovascular risk in a sample of patients with pre-hypertension or first-degree hypertension.

Keywords: Blood pressure; Clinical evidence; Clinical trial; Dietary supplements; Hypertension; Nutraceuticals.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Antihypertensive Agents / administration & dosage*
  • Blood Pressure / drug effects*
  • Combined Modality Therapy
  • Diet, Healthy*
  • Diet, Mediterranean
  • Diet, Sodium-Restricted
  • Dietary Approaches To Stop Hypertension*
  • Dietary Supplements*
  • Double-Blind Method
  • Female
  • Humans
  • Hypertension / diagnosis
  • Hypertension / physiopathology
  • Hypertension / therapy*
  • Italy
  • Magnesium / administration & dosage
  • Male
  • Middle Aged
  • Nitric Oxide Donors / administration & dosage
  • Pilot Projects
  • Time Factors
  • Treatment Outcome
  • Vitamins / administration & dosage


  • Antihypertensive Agents
  • Nitric Oxide Donors
  • Vitamins
  • Magnesium