Prognostic factors and survival outcomes for head and neck cutaneous adnexal cancers

Am J Otolaryngol. 2019 Jan-Feb;40(1):110-114. doi: 10.1016/j.amjoto.2018.09.011. Epub 2018 Sep 22.


Objectives: Malignant cutaneous adnexal tumors (MCAT) are rare and comprise a heterogeneous group of cancers. There have been several studies reviewing prognostic factors of these tumors, but no studies focusing on the head and neck. This study aimed to review a large population based database to evaluate prognostic factors that could impact survival.

Methods: The Surveillance, Epidemiology, and End Results (SEER) database was utilized to identify patients with MCAT of the head and neck. Both overall and disease specific survival were the main outcome measures for the study. Univariate and multivariate analyses were performed to evaluate the association of suspected prognostic factors with survival.

Results: The five-year OS and DSS were 72.6 and 95.5%, respectively. A favorable factor for OS was surgical resection ([HR] 0.324; P = 0.001), while unfavorable factors for OS include older age (1.051; P < 0.001), higher tumor grade (1.254; P = 0.049), larger tumor size (1.293; P = 0.003), and positive nodal involvement (3.323; P = 0.002). A favorable factor for DSS was surgical resection (0.026; P < 0.001). Unfavorable factors for DSS include older age (1.058; P = 0.046), larger tumor size (2.528; 1.565-4.085; P < 0.001), and positive nodal involvement (4.761; P = 0.022).

Conclusion: Review of the SEER database shows good 5-year OS and DSS rates, similar to those cited in other studies. We identified several prognostic factors associated with survival, while histologic sub-type does not seem to be associated with survival. Surgical resection is the mainstay of treatment.

Keywords: Apocrine; Disease specific survival; Eccrine; Malignant cutaneous adnexal carcinoma; Overall survival.

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Carcinoma / mortality*
  • Carcinoma / pathology*
  • Carcinoma / therapy
  • Female
  • Head and Neck Neoplasms / mortality*
  • Head and Neck Neoplasms / pathology*
  • Head and Neck Neoplasms / therapy
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Outcome Assessment, Health Care
  • Retrospective Studies
  • SEER Program
  • Survival Rate
  • Sweat Gland Neoplasms / mortality*
  • Sweat Gland Neoplasms / pathology*
  • Sweat Gland Neoplasms / therapy
  • United States