Purinergic signaling in Alzheimer's disease

Brain Res Bull. 2019 Sep:151:25-37. doi: 10.1016/j.brainresbull.2018.10.014. Epub 2018 Nov 22.


Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized by three major histopathological markers: amyloid-β (Aβ) plaques, neurofibrillary tangles and gliosis in the central nervous system (CNS). It is now accepted that neuroinflammatory events in the CNS play a crucial role in the development of AD. This review focuses on neuroinflammatory signaling mediated by purinergic receptors (P1 adenosine receptors, P2X ATP-gated ion channels and G protein-coupled P2Y nucleotide receptors) and how therapeutic modulation of purinergic signaling influences disease progression in AD patients and animal models of AD.

Keywords: Alzheimer’s disease; Neuroinflammation; P1 receptor; P2X receptor; P2Y receptor.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine Triphosphate
  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / pathology
  • Animals
  • Central Nervous System / physiology
  • Disease Models, Animal
  • Humans
  • Plaque, Amyloid / metabolism
  • Purines / metabolism
  • Receptors, Purinergic / metabolism*
  • Receptors, Purinergic / physiology*
  • Receptors, Purinergic P1 / metabolism
  • Receptors, Purinergic P2X / metabolism
  • Receptors, Purinergic P2Y / metabolism
  • Signal Transduction / physiology


  • Purines
  • Receptors, Purinergic
  • Receptors, Purinergic P1
  • Receptors, Purinergic P2X
  • Receptors, Purinergic P2Y
  • Adenosine Triphosphate