Enhancement of Declarative Memory: From Genetic Regulation to Non-invasive Stimulation

Biochemistry (Mosc). 2018 Sep;83(9):1124-1138. doi: 10.1134/S0006297918090146.

Abstract

The problem of memory enhancement is extremely important in intellectual activity areas and therapy of different types of dementia, including Alzheimer's disease (AD). The attempts to solve this problem have come from different research fields. In the first part of our review, we describe the results of targeting certain genes involved in memory-associated molecular pathways. The second part of the review is focused on the deep stimulation of brain structures that can slow down memory loss in AD. The third part describes the results of the use of non-invasive brain stimulation techniques for memory modulation, consolidation, and retrieval in healthy people and animal models. Integration of data from different research fields is essential for the development of efficient strategies for memory enhancement.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / metabolism
  • Alzheimer Disease / pathology*
  • Alzheimer Disease / therapy
  • Animals
  • Brain / metabolism*
  • CREB-Binding Protein / genetics
  • CREB-Binding Protein / metabolism
  • Deep Brain Stimulation
  • Gene Expression Regulation
  • Humans
  • Insulin-Like Growth Factor II / genetics
  • Insulin-Like Growth Factor II / metabolism
  • Memory*

Substances

  • Insulin-Like Growth Factor II
  • CREB-Binding Protein