A randomized clinical trial of phenelzine and imipramine for posttraumatic stress disorder

Am J Psychiatry. 1988 Oct;145(10):1289-91. doi: 10.1176/ajp.145.10.1289.


In a double-blind, randomized clinical trial, the efficacy of imipramine and of phenelzine was compared with that of placebo in 34 male veterans with posttraumatic stress disorder (PTSD). Both medications reduced PTSD symptoms.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Clinical Trials as Topic
  • Humans
  • Imipramine / therapeutic use*
  • Male
  • Phenelzine / therapeutic use*
  • Placebos
  • Psychiatric Status Rating Scales
  • Random Allocation
  • Stress Disorders, Post-Traumatic / drug therapy*
  • Stress Disorders, Post-Traumatic / psychology


  • Placebos
  • Phenelzine
  • Imipramine