The ins and outs of telomere crisis in cancer

Genome Med. 2018 Nov 27;10(1):89. doi: 10.1186/s13073-018-0596-4.

Abstract

Telomere crisis is linked with many of the genomic alterations found in cancer genomes. A new understanding of how these alterations arise points towards an active role for innate immune sensors during crisis and to new opportunities for the treatment and diagnosis of cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA Damage
  • Genome
  • Humans
  • Neoplasms / genetics*
  • Telomere*