Studies of a common idiotype PR4 in autoimmune rheumatic disease

Arthritis Rheum. 1988 Sep;31(9):1097-104. doi: 10.1002/art.1780310903.


A new common idiotype, designated PR4, is described. This idiotype was originally identified on a human hybridoma-derived monoclonal antibody from a patient with leprosy, which binds the major Mycobacterium leprae-derived antigen, phenolic glycolipid-1, poly(ADP)-ribose, DNA, and poly(dT). The PR4 idiotype was found in patients with systemic lupus erythematosus (SLE) (70%), rheumatoid arthritis (40%), and Sjögren's syndrome (15%). It was not, however, found in the spouses of the SLE patients or (unlike other lupus idiotypes) in their healthy first-degree relatives. Although no correlation between PR4 idiotype levels and disease activity in SLE was found, a subset of rheumatoid arthritis patients with high levels of the idiotype was identified.

MeSH terms

  • Antibodies, Anti-Idiotypic / immunology
  • Antigens, Bacterial / immunology
  • Arthritis, Rheumatoid / blood
  • Arthritis, Rheumatoid / immunology
  • Autoimmune Diseases / immunology*
  • DNA / metabolism
  • DNA, Single-Stranded / immunology
  • Enzyme-Linked Immunosorbent Assay / methods
  • Humans
  • Immunoglobulin Idiotypes / analysis*
  • Immunoglobulins / immunology
  • Lupus Erythematosus, Systemic / blood
  • Lupus Erythematosus, Systemic / immunology
  • Lupus Erythematosus, Systemic / physiopathology
  • Mycobacterium leprae / immunology
  • Reference Values
  • Rheumatic Diseases / immunology*
  • Severity of Illness Index
  • Sjogren's Syndrome / immunology


  • Antibodies, Anti-Idiotypic
  • Antigens, Bacterial
  • DNA, Single-Stranded
  • Immunoglobulin Idiotypes
  • Immunoglobulins
  • DNA