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, 27 (6), 1781-1789

Antihypertensive Peptides From Whey Proteins Fermented by Lactic Acid Bacteria


Antihypertensive Peptides From Whey Proteins Fermented by Lactic Acid Bacteria

Eric Banan-Mwine Daliri et al. Food Sci Biotechnol.


In this study, whey proteins were fermented with 34 lactic acid bacteria for 48 h at 37 °C and their ability to inhibit angiotensin 1-converting enzyme (ACE) activity were compared. All the lactic acid bacteria displayed varying proteolytic abilities in whey. Their fermentates also displayed varying abilities to inhibit ACE in vitro. Seven fermentates showed strong ACE inhibitory abilities between 84.70 ± 0.67 and 52.40 ± 2.1% with IC50 values between 19.78 ± 1.73 and 2.13 ± 0.7 mg/ml. Pediococcus acidilactici SDL1414 showed the strongest ACE inhibitory activity of 84.7 ± 0.67% (IC50 = 19.78 ± 1.73 μg/ml). Mass spectrometry revealed that more than half (57.7%) of the low molecular weight peptides (< 7 kDa) in the P. acidilactici SDL1414 fermented samples were ACE inhibitory peptides. Our results show that P. acidilactici SDL1414 could be used as a starter culture in the dairy industry to develop antihypertensive functional foods for hypertension management.

Keywords: Angiotensin1-converting enzyme; Bioactive peptides; Fermentates.

Conflict of interest statement

Compliance with ethical standardsThe authors declare that they have no conflict of interest.


Fig. 1
Fig. 1
The degree of whey hydrolysis by 34 lactic acid bacteria after 48 h fermentation at 37 °C. Degree of hydrolysis is mean ± SEM of three independent experiments. Bars with different alphabets are significantly different (p < 0.05). Legend: 1—L. rhamnosus JDFM6; 2—P. Pentosaceus SDL1415; 3—P. Pentosaceus SDL1416; 4—L. rhamnosus JDFM33; 5—E. lactis SCL1421; 6—P. acidilacti SDL1405; 7—W. confusa SCSB2320; 8—P. acidilactici SDL1414; 9—S. thermophillus SCML300; 10—Ent. Faecalis MAD13; 11—L. planterum JDFM44; 12—Ent. fecium SC54; 13—P. acidilactici SCL1420; 14—W. koreensis JBNU2; 15—L. pentosus SC48; 16—Leu. paramesenteroides SC46; 17—P. acidilactici SKL1418; 18—L. brevis SDL1408; 19—L. brevis SDL1411; 20—W. confusa SCKB2318; 21—L. curvatus JBNU38; 22—Ent. fecium CK5; 23—S. thermophilus SCML337; 24—L. plantarum SDL1413; 25—L. arizonensis SC27; 26—L. pentosaceus SDL1409; 27—L. pentosus SDL1401; 28—P. acidilactici SDL1406; 29—Leu. mesenteroides JBNU10; 30—W. cibaria SCCB2306; 31—P. pentosaceus SDL1416; 32—P. acidilactici DM9; 33—P. pentosaceus MAC11; 34—L. citrium SC53

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