Role of the PAQosome in Regulating Arrangement of Protein Quaternary Structure in Health and Disease

Adv Exp Med Biol. 2018;1106:25-36. doi: 10.1007/978-3-030-00737-9_3.


The PAQosome, formerly known as the R2TP/PFDL complex, is an eleven-subunit cochaperone complex that assists HSP90 in the assembly of numerous large multisubunit protein complexes involved in essential cellular functions such as protein synthesis, ribosome biogenesis, transcription, splicing, and others. In this review, we discuss possible mechanisms of action and role of phosphorylation in the assembly of client complexes by the PAQosome as well as its potential role in cancer, ciliogenesis and ciliopathies.

Keywords: Cancer; Chaperone; Ciliopathies; Cilium; Interactome; PAQosome; PDRG1; Phosphorylation; Prefoldin-like; Protein complex assembly; Protein network; Quaternary structure arrangement; R2TP; URI1; UXT.

Publication types

  • Review

MeSH terms

  • Ciliopathies
  • HSP90 Heat-Shock Proteins / chemistry*
  • Humans
  • Molecular Chaperones / chemistry*
  • Neoplasms
  • Phosphorylation
  • Protein Structure, Quaternary*


  • HSP90 Heat-Shock Proteins
  • Molecular Chaperones