Language lateralization with resting-state and task-based functional MRI in pediatric epilepsy

J Neurosurg Pediatr. 2018 Oct 19;23(2):171-177. doi: 10.3171/2018.7.PEDS18162.


In Brief: The study compared two types of functional MRI (fMRI) to see which side of the brain is most responsible for language: traditional task-based fMRI, which requires a high level of patient interaction, and resting-state fMRI, which is typically performed with the patient under light sedation and has no interaction requirement. The authors found that the test correlation was 93%, indicating resting state fMRI has potential to locate language in those unable to participate in task-based fMRI.

Keywords: BOLD = blood oxygen level–dependent; RSN = resting-state network; fMRI = functional MRI; language lateralization; pediatric epilepsy; resting-state fMRI; resting-state functional MRI; rs-fMRI = resting-state fMRI; surgical technique; task-based fMRI; task-based functional MRI; tb-fMRI = task-based fMRI.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Brain Mapping / methods
  • Epilepsy / diagnostic imaging
  • Epilepsy / physiopathology*
  • Female
  • Functional Laterality / physiology*
  • Humans
  • Language*
  • Magnetic Resonance Imaging / methods*
  • Magnetic Resonance Imaging / statistics & numerical data
  • Male
  • Retrospective Studies