Acute effect of soy and soy products on serum uric acid concentration among healthy Chinese men

Asia Pac J Clin Nutr. 2018;27(6):1239-1242. doi: 10.6133/apjcn.201811_27(6).0010.


Background and objectives: Soy products are essential to the daily life of the Chinese population. However, the association between soy products and serum uric acid remains unclear. Better understanding of their relationship could provide food choice information for patients with gout. This study assessed the acute effects of soy and soy products on serum uric acid.

Methods and study design: Sixty healthy adult male volunteers were recruited and randomly assigned to six groups. Ten participants in each group randomly ingested one of six foods: water, soy, and four different soy products. A blood test was conducted after 3 h to examine uric acid concentration.

Results: The serum uric acid concentration significantly increased by 21.4±23.4 μmol/L at 1 h and 16.3±19.4 μmol/L at 2 h following ingestion of whole soybeans. These changes also applied to the soy powder group. The serum uric acid concentration rapidly increased by 38.1±20.5 μmol/L at 1 h, 34.4±18.2 μmol/L at 2 h, and 24.1±24.2 μmol/L at 3 h after the ingestion of soybean milk. The maximum concentration of serum uric acid was observed at 1 h after intake of soybeans and soy products, and then gradually decreased during the subsequent 2-h period. No significant uric acid changes from ingesting bean curd cake and dried bean curd stick were detected.

Conclusions: Ingesting different soy products resulted in different concentrations of serum uric acid, with soybeans, soybean milk, and soy powder considerably increasing serum uric acid.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Asian People
  • China
  • Glycine max / adverse effects*
  • Humans
  • Male
  • Seeds
  • Soy Foods / adverse effects*
  • Soy Milk / administration & dosage
  • Uric Acid / blood*


  • Uric Acid