Hippocampal expression of cell-adhesion glycoprotein neuroplastin is altered in Alzheimer's disease

J Cell Mol Med. 2019 Feb;23(2):1602-1607. doi: 10.1111/jcmm.13998. Epub 2018 Nov 28.


Cell-adhesion glycoprotein neuroplastin (Np) is involved in the regulation of synaptic plasticity and balancing hippocampal excitatory/inhibitory inputs which aids in the process of associative memory formation and learning. Our recent findings show that neuroplastin expression in the adult human hippocampus is specifically associated with major hippocampal excitatory pathways and is related to neuronal calcium regulation. Here, we investigated the hippocampal expression of brain-specific neuroplastin isoform (Np65), its relationship with amyloid and tau pathology in Alzheimer's disease (AD), and potential involvement of neuroplastin in tissue response during the disease progression. Np65 expression and localization was analysed in six human hippocampi with confirmed AD neuropathology, and six age-/gender-matched control hippocampi by imunohistochemistry. In AD cases with shorter disease duration, the Np65 immunoreactivity was significantly increased in the dentate gyrus (DG), Cornu Ammonis 2/3 (CA2/3), and subiculum, with the highest level of Np expression being located on the dendrites of granule cells and subicular pyramidal neurons. Changes in the expression of neuroplastin in AD hippocampal areas seem to be related to the progression of disease. Our study suggests that cell-adhesion protein neuroplastin is involved in tissue reorganization and is a potential molecular marker of plasticity response in the early neurodegeneration process of AD.

Keywords: cell-adhesion molecules; human hippocampus; immunohistochemistry; neurodegeneration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / genetics*
  • Alzheimer Disease / metabolism
  • Alzheimer Disease / pathology
  • Amyloid / genetics
  • Amyloid / metabolism
  • Autopsy
  • Calcium / metabolism
  • Calcium Signaling
  • Case-Control Studies
  • Disease Progression
  • Female
  • Gene Expression
  • Hippocampus / metabolism*
  • Hippocampus / pathology
  • Humans
  • Male
  • Membrane Glycoproteins / genetics*
  • Membrane Glycoproteins / metabolism
  • Neuronal Plasticity / genetics*
  • Neurons / metabolism*
  • Neurons / pathology
  • Protein Isoforms / genetics
  • Protein Isoforms / metabolism
  • Synapses / genetics
  • Synapses / metabolism
  • Synapses / pathology
  • Synaptic Transmission / genetics
  • tau Proteins / genetics*
  • tau Proteins / metabolism


  • Amyloid
  • MAPT protein, human
  • Membrane Glycoproteins
  • NPTN protein, human
  • Protein Isoforms
  • tau Proteins
  • Calcium