The evolution of toxic anterior segment syndrome

Curr Opin Ophthalmol. 2019 Jan;30(1):50-55. doi: 10.1097/ICU.0000000000000540.


Purpose of review: Toxic anterior segment syndrome (TASS) is a surgical complication resulting from a noninfectious inflammatory reaction to substances used during intraocular ophthalmic surgery. Continuous reporting of new information concerning risk factors and possible causes is critical for preventing this condition.

Recent findings: The diagnosis of TASS is clinical and its main features are well known. However, new causes of TASS are emerging and being reported, as are new treatment options for managing the inflammation or its complications, and prevention guidelines are being updated. This article presents current and novel information regarding these topics.

Summary: Educating the medical community regarding potential causes of TASS and its prevention is necessary for improving management of TASS. Thorough investigations and reports of TASS cases are a fundamental step in achieving this goal. Still, as the complete eradication of TASS solely through prevention is unlikely, further studies regarding TASS's pathophysiology, systemic and ocular risk factors, and new treatment options are necessary.

Publication types

  • Review

MeSH terms

  • Anterior Eye Segment / pathology*
  • Eye Diseases / diagnosis
  • Eye Diseases / etiology*
  • Eye Diseases / prevention & control
  • Humans
  • Phacoemulsification / adverse effects*
  • Postoperative Complications
  • Risk Factors
  • Viscoelastic Substances / adverse effects*


  • Viscoelastic Substances