canSAR: update to the cancer translational research and drug discovery knowledgebase

Nucleic Acids Res. 2019 Jan 8;47(D1):D917-D922. doi: 10.1093/nar/gky1129.

Abstract

canSAR (http://cansar.icr.ac.uk) is a public, freely available, integrative translational research and drug discovery knowlegebase. canSAR informs researchers to help solve key bottlenecks in cancer translation and drug discovery. It integrates genomic, protein, pharmacological, drug and chemical data with structural biology, protein networks and unique, comprehensive and orthogonal 'druggability' assessments. canSAR is widely used internationally by academia and industry. Here we describe major enhancements to canSAR including new and expanded data. We also describe the first components of canSARblack-an advanced, responsive, multi-device compatible redesign of canSAR with a question-led interface.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents* / chemistry
  • Antineoplastic Agents* / therapeutic use
  • Databases, Pharmaceutical*
  • Drug Discovery*
  • Humans
  • Knowledge Bases*
  • Neoplasms / drug therapy
  • Neoplasms / genetics
  • Protein Conformation
  • Protein Interaction Mapping
  • Translational Medical Research
  • User-Computer Interface

Substances

  • Antineoplastic Agents