Vancomycin Should Be Part of Empiric Therapy for Suspected Bacterial Meningitis

J Pediatric Infect Dis Soc. 2019 May 11;8(2):187-188. doi: 10.1093/jpids/piy121.


The use of empiric vancomycin plus a third-generation cephalosporin for suspected bacterial meningitis has been recommended since 1997. Although the prevalence of ceftriaxone-nonsusceptible pneumococcal meningitis has decreased, vancomycin should still be included as empiric therapy for bacterial meningitis.

Keywords: Streptococcus pneumoniae; bacterial meningitis; pediatric; vancomycin.

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Ceftriaxone / therapeutic use
  • Cephalosporins / therapeutic use
  • Drug Resistance, Multiple, Bacterial / drug effects
  • Drug Therapy, Combination
  • Humans
  • Meningitis, Bacterial / drug therapy*
  • Meningitis, Pneumococcal / drug therapy
  • Microbial Sensitivity Tests
  • Streptococcus pneumoniae / drug effects
  • Vancomycin / therapeutic use*


  • Anti-Bacterial Agents
  • Cephalosporins
  • Vancomycin
  • Ceftriaxone