Highly Functionalized Ring B Labdane Synthesis as Key Intermediate in the Route to Forskolin

Nat Prod Commun. 2017 May;12(5):667-670.


Sclareol has been employed as starting material for the synthesis of several advanced intermediates towards the synthesis of highly ring B oxygenated labdanes. Dinorlabdanes 6,7,8,9-tetraoxygenated with 6,7-dioxygenated functionalities with a-cis or O-cis dispositions, have been prepared and can be used for forskolin or analogues synthesis.

MeSH terms

  • Colforsin / chemical synthesis*
  • Diterpenes / chemical synthesis*
  • Molecular Structure


  • Diterpenes
  • labdane
  • Colforsin