Cutaneous B-Cell Lymphoma

Hematol Oncol Clin North Am. 2019 Feb;33(1):149-161. doi: 10.1016/j.hoc.2018.08.006.


Primary cutaneous B-cell lymphomas are non-Hodgkin lymphomas that present in the skin without evidence of extracutaneous involvement at diagnosis. There are 3 types of primary cutaneous B-cell lymphomas: primary cutaneous marginal zone lymphoma, primary cutaneous follicle center lymphoma, and primary cutaneous diffuse large B-cell lymphoma, leg-type. Because it is most frequently diagnosed on skin biopsy, intravascular large B-cell lymphoma is commonly included with pcBCL. A complicating factor in diagnosing primary cutaneous B-cell lymphomas is that they can appear histologically identical to their extracutaneous counterparts. This review summarizes the clinical presentation, histopathology, evaluation, treatment, and differential diagnosis of these lymphomas.

Keywords: Intravascular large B-cell lymphoma; Primary cutaneous B-cell lymphoma; Primary cutaneous diffuse large B-cell lymphoma; Primary cutaneous follicle center lymphoma; Primary cutaneous marginal zone lymphoma.

Publication types

  • Review

MeSH terms

  • Biopsy
  • Diagnosis, Differential
  • Disease Management
  • Disease Susceptibility
  • Humans
  • Immunohistochemistry
  • Lymphoma, B-Cell / diagnosis*
  • Lymphoma, B-Cell / etiology*
  • Lymphoma, B-Cell / therapy
  • Neoplasm Staging
  • Prognosis
  • Skin / pathology
  • Skin Neoplasms / diagnosis*
  • Skin Neoplasms / etiology*
  • Skin Neoplasms / therapy