Effects of a sea buckthorn oil spray emulsion on dry eye

Cont Lens Anterior Eye. 2019 Aug;42(4):428-433. doi: 10.1016/j.clae.2018.11.011. Epub 2018 Nov 26.


Purpose: To investigate the effects of a sea buckthorn oil and sodium hyaluronate-containing eyelid spray emulsion (SB spray) on dry eye.

Methods: A randomized controlled study was carried out. Adults (25-70 years) with Ocular Surface Disease Index (OSDI) ≥20 and moderate or severe dryness, burning or grittiness of the eyes were included. In study part one (n = 2), SB spray was used on both closed eyelids four times in one day. In part two (n = 10), SB spray was used on one randomized eyelid, and a commercial reference spray on the other for nine days. In part three (n = 40), eyes were randomized to one eye receiving SB spray and an untreated control for 1.5 months. Dry eye tests were carried out at baseline, during, and at the end of each study section. Symptoms were recorded in questionnaires and daily logs.

Results: In part one, the SB spray was well tolerated. In part two, OSDI decreased significantly (P = 0.022) in the SB spray eye compared to the reference spray, indicating a beneficial effect on symptoms. In part three, OSDI in the SB spray eye decreased significantly compared to the untreated control (P = 0.0007). The scores for dryness at the study end were lower in the SB spray eye compared to control (P = 0.0070). Symptom sums and frequencies of dryness (sum P = 0.0046, frequency P = 0.0016) and watering (sum P = 0.0003, frequency P = 0.013) in the daily logs were lower in the eye treated with SB spray.

Conclusions: SB spray on closed eyelids relieved the symptoms of dry eye.

Keywords: Dry eye; Eyelid spray; Hyaluronic acid; Sea buckthorn oil.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aerosols*
  • Aged
  • Dry Eye Syndromes / diagnosis
  • Dry Eye Syndromes / drug therapy*
  • Dry Eye Syndromes / physiopathology
  • Emulsions / chemistry
  • Female
  • Hippophae / chemistry*
  • Humans
  • Hyaluronic Acid / chemistry
  • Hyaluronic Acid / therapeutic use*
  • Male
  • Middle Aged
  • Nebulizers and Vaporizers
  • Ophthalmic Solutions
  • Osmolar Concentration
  • Plant Oils / chemistry
  • Plant Oils / therapeutic use*
  • Seeds / chemistry
  • Surveys and Questionnaires
  • Tears / chemistry
  • Tears / physiology


  • Aerosols
  • Emulsions
  • Ophthalmic Solutions
  • Plant Oils
  • Hyaluronic Acid