Clinical comparison of topical solutions containing trimethoprim in treating ocular surface bacterial infections

J Ocul Pharmacol. Summer 1988;4(2):111-5. doi: 10.1089/jop.1988.4.111.


Thirty-nine patients with bacterial ocular surface infections (conjunctivitis, blepharitis or blepharoconjunctivitis) were evaluated after treatment with a topically applied ophthalmic solution containing trimethoprim. A combination of trimethoprim and polymixin B (TP) produced identical clinical and microbiologic responses when compared to a solution containing, in addition to trimethoprim and polymyxin B, sulfacetamide. The sulfa component was not essential to produce desired clinical and microbiologic results.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Bacterial Infections / drug therapy*
  • Clinical Trials as Topic
  • Double-Blind Method
  • Drug Therapy, Combination
  • Eye Diseases / drug therapy*
  • Follow-Up Studies
  • Humans
  • Polymyxin B / administration & dosage
  • Polymyxin B / therapeutic use
  • Random Allocation
  • Sulfacetamide / administration & dosage
  • Sulfacetamide / therapeutic use
  • Trimethoprim / administration & dosage
  • Trimethoprim / therapeutic use*


  • Sulfacetamide
  • Trimethoprim
  • Polymyxin B