This study investigated the potential role of sex and handedness on the performance of a computerised Wisconsin Card Sorting Test (WCST) in healthy participants by applying functional near-infrared spectroscopy (fNIRS). We demonstrated significant (p < 0.05) sex-related differences of hemodynamic response in the prefrontal cortex of 70 healthy participants (female, n = 35 and male, n = 35; right-handed, n = 40 and left-handed, n = 30). In contrast, behavioural results of the WCST do not show sex bias, which is consistent with previous literature. Because of this, we compared ours and sparse previous fNIRS studies on the WCST. We propose that, according to recent studies of neurovascular coupling, this contradiction between neuroimaging and behavioural results may be explained by normal variability in neurovascular dynamics.
Keywords: Gender; Handedness; Hemodynamics; Near-infrared spectroscopy; Neurovasculature; Prefrontal cortex; Sex; WCST; fNIRS.