Recognising Lung Cancer in Primary Care

Adv Ther. 2019 Jan;36(1):19-30. doi: 10.1007/s12325-018-0843-5. Epub 2018 Nov 29.


Significant advances in the management of both early and advanced stage lung cancer have not yet led to the scale of improved outcomes which have been achieved in other cancers over the last 40 years. Diagnosis of lung cancer at the earliest stage of disease is strongly associated with improved survival. Therefore, although recent advances in oncology may herald breakthroughs in effective treatment, achieving early diagnosis will remain crucial to obtaining optimal outcomes. This is challenging, as most lung cancer symptoms are non-specific or are common respiratory symptoms which usually represent benign disease. Identification of patients at risk of lung cancer who require further investigation is an important responsibility for general practitioners (GPs). Diagnosis has historically relied upon plain chest X-ray (CXR), organised in response to symptoms. The sensitivity of this modality, however, compares unfavourably with that of computed tomography (CT). In some jurisdictions screening high-risk individuals with low dose CT (LDCT) is now recommended. However uptake remains low and the eligibility for screening programmes is restricted. Therefore, even if screening is widely adopted, most patients will continue to be diagnosed after presenting with symptoms. Achieving early diagnosis requires GPs to maintain an appropriate level of suspicion and readiness to investigate in high-risk patients or those with non-resolving symptoms. This article discusses the early detection of lung cancer from a primary care perspective. We outline risk factors and epidemiology, the role of screening and offer guidance on the recognition of symptomatic presentation and the investigation and referral of suspected lung cancer.

Keywords: CT chest; Cancer diagnosis; Chest X-ray; GP; General practitioner; Lung cancer; Lung cancer screening; Oncology; Primary care.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Early Detection of Cancer / statistics & numerical data*
  • Humans
  • Lung Neoplasms / diagnosis*
  • Lung Neoplasms / diagnostic imaging
  • Male
  • Mass Screening / methods
  • Physician's Role
  • Primary Health Care / organization & administration*
  • Risk Factors
  • Tomography, X-Ray Computed / methods

Associated data

  • figshare/10.6084/m9.figshare.7334852