p62/SQSTM1: 'Jack of all trades' in health and cancer

FEBS J. 2019 Jan;286(1):8-23. doi: 10.1111/febs.14712. Epub 2018 Dec 18.


p62 is a stress-inducible protein able to change among binding partners, cellular localizations and form liquid droplet structures in a context-dependent manner. This protein is mainly defined as a cargo receptor for selective autophagy, a process that allows the degradation of detrimental and unnecessary components through the lysosome. Besides this role, its ability to interact with multiple binding partners allows p62 to act as a main regulator of the activation of the Nrf2, mTORC1, and NF-κB signaling pathways, linking p62 to the oxidative defense system, nutrient sensing, and inflammation, respectively. In the present review, we will present the molecular mechanisms behind the control p62 exerts over these pathways, their interconnection and how their deregulation contributes to cancer progression.

Keywords: Keap1; NF-κB; Nrf2; autophagy; cancer; mTORC1; p62/SQSTM1.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Inflammation / physiopathology*
  • Neoplasms / physiopathology*
  • Oxidative Stress
  • RNA-Binding Proteins / metabolism*
  • Sequestosome-1 Protein / metabolism*
  • Signal Transduction


  • P62 protein, human
  • RNA-Binding Proteins
  • SQSTM1 protein, human
  • Sequestosome-1 Protein