Burkitt Leukemia With Precursor B-Cell Immunophenotype and Dual Translocation of t(14;18) and t(8;14) in a Child: Case Report and Review of the Literature

J Pediatr Hematol Oncol. 2020 Jan;42(1):e61-e63. doi: 10.1097/MPH.0000000000001354.

Abstract

Background: Burkitt leukemia (BL) with the precursor B-cell immunophenotype is a rarely reported condition. The prognosis of such patients is similar to that of classic BL. However, the combination of chromosomal translocations associated with bcl-2 and c-myc rearrangement has a poor prognosis.

Observations: An 11-year-old child presented with fever and weakness. Bone marrow aspiration showed morphologically L1 type blasts and flow cytometry analysis was compatible with precursor B-cell immunophenotype. Cytogenetic analysis revealed a combination of t(8;14) and t(14;l8).

Conclusions: The combination of t(8;14) and t(14;l8) can exhibit different immunophenotypical and morphologic features in leukemias.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Burkitt Lymphoma* / blood
  • Burkitt Lymphoma* / genetics
  • Burkitt Lymphoma* / immunology
  • Burkitt Lymphoma* / pathology
  • Child
  • Chromosomes, Human / genetics*
  • Cytogenetic Analysis
  • Flow Cytometry
  • Humans
  • Immunophenotyping
  • Male
  • Precursor Cells, B-Lymphoid* / immunology
  • Precursor Cells, B-Lymphoid* / metabolism
  • Precursor Cells, B-Lymphoid* / pathology
  • Proto-Oncogene Proteins c-bcl-2 / genetics
  • Proto-Oncogene Proteins c-bcl-2 / immunology
  • Proto-Oncogene Proteins c-myc / genetics
  • Proto-Oncogene Proteins c-myc / immunology
  • Translocation, Genetic*

Substances

  • BCL2 protein, human
  • MYC protein, human
  • Proto-Oncogene Proteins c-bcl-2
  • Proto-Oncogene Proteins c-myc