IL-4Rα-expressing CD11c+ cells contribute to driving optimal cellular responses during Schistosoma mansoni infection in mice

J Leukoc Biol. 2019 Feb;105(2):307-316. doi: 10.1002/JLB.MA0318-115R. Epub 2018 Nov 30.


Development of IL-4 receptor alpha (IL-4Rα)-dependent cellular immunity regulates host protection against acute schistosomiasis. In this study, we investigated the importance of IL-4Rα-expressing CD11c+ cells in driving the development of optimal cellular responses to Schistosoma mansoni infection by using CD11ccre IL-4Rα-/lox BALB/c mice, which lacked IL-4Rα expression on dendritic cells and alveolar macrophages. Abrogation of IL-4Rα expression on CD11c+ cells affected activation of CD4+ T cells, resulting in reduced numbers of effector CD4+ T cells and impaired production of Th1 and Th2 cytokines by CD4+ T cells ex vivo. However, secretion of both type 1 and type 2 Ab isotypes was unchanged in infected CD11c-specific IL-4Rα-deficient mice compared to littermate controls. Together, these data demonstrate that IL-4Rα-expressing CD11c+ cells play an important role in maintaining cellular immunity during schistosomiasis in mice.

Keywords: CD11c+ cells; IL-4Rα; acute; immunity; mice; schistosomiasis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Helminth / immunology
  • CD11c Antigen / metabolism*
  • CD4-Positive T-Lymphocytes / immunology
  • Cytokines / metabolism
  • Immunoglobulin E / biosynthesis
  • Immunoglobulin G / biosynthesis
  • Inflammation / pathology
  • Liver / parasitology
  • Liver / pathology
  • Lymph Nodes / pathology
  • Mice, Inbred BALB C
  • Receptors, Cell Surface / deficiency
  • Receptors, Cell Surface / metabolism*
  • Schistosoma mansoni / pathogenicity*
  • Schistosomiasis mansoni / immunology*
  • Schistosomiasis mansoni / pathology
  • Th1 Cells / immunology
  • Th2 Cells / immunology


  • Antibodies, Helminth
  • CD11c Antigen
  • Cytokines
  • Il4ra protein, mouse
  • Immunoglobulin G
  • Receptors, Cell Surface
  • Immunoglobulin E