Protective potentials of far-infrared ray against neuropsychotoxic conditions

Neurochem Int. 2019 Jan:122:144-148. doi: 10.1016/j.neuint.2018.11.019. Epub 2018 Nov 28.


Compelling evidence suggests that far-infrared ray (FIR) possesses beneficial effects on emotional disorders. However, the underlying mechanism conveyed by FIR remains unclear. Recently, we demonstrated that exposure to FIR induces antioxidant potentials via up-regulation of glutathione peroxidase (GPx)-1 gene. The antioxidant potentials might be important for the modulation on the neuropsychotoxic conditions. Exposure to FIR protects from methamphetamine (MA)-induced memory impairments via phosphorylation of ERK 1/2 signaling by positive modulation of protein kinase C δ (PKCδ), M1 muscarinic acetylcholine receptor (M1 mAChR), and nuclear factor E2-related factor 2 (Nrf2) transcription factor. In addition, exposure to FIR positively modulates MA-induced behavioral sensitization via attenuating mitochondrial dysfunction by down-regulation of dopamine D1 receptor. In this mini-review, we have discussed with the protective potentials mediated by FIR against MA-induced psychotoxic burdens.

Keywords: Behavioral sensitization; Far-infrared ray; Glutathione peroxidase-1 gene; Memory impairments; Methamphetamine.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antioxidants / pharmacology
  • Humans
  • Infrared Rays / therapeutic use
  • Methamphetamine / pharmacology*
  • Mitochondria / drug effects*
  • Mitochondria / metabolism
  • Protein Kinase C-delta / drug effects*
  • Protein Kinase C-delta / metabolism
  • Receptors, Dopamine D1 / drug effects*
  • Receptors, Dopamine D1 / metabolism


  • Antioxidants
  • Receptors, Dopamine D1
  • Methamphetamine
  • Protein Kinase C-delta