Treatment of psychiatric disturbances in common hyperkinetic movement disorders

Expert Rev Neurother. 2019 Jan;19(1):55-65. doi: 10.1080/14737175.2019.1555475. Epub 2018 Dec 10.


Introduction: This paper reviews studies that have assessed the treatment of psychiatric disturbances in dystonia, tic disorders, Tourette syndrome, Huntington's disease, and essential tremor. Areas covered: We searched for papers in English in Pubmed using the following keywords: blepharospasm, cervical dystonia, arm dystonia, laryngeal dystonia, spasmodic dysphonia, tic disorders, Tourette syndrome, Huntington's chorea, essential tremor, depression, anxiety, obsessive compulsive disorders, attention deficit hyperactivity disorders, psychosis, apathy. Expert commentary: Although psychiatric disturbances are frequent in hyperkinetic movement disorders, few controlled studies have assessed the treatment of psychiatric disturbances in such disorders. In dystonia, none of the controlled studies conducted to date have demonstrated the efficacy of drug treatment for depression or anxiety. In TS, controlled studies have demonstrated the usefulness of drug treatment on obsessive compulsive disorders and attention deficit hyperactivity disorders. Behavioral interventions may also play a role. No controlled studies have been conducted on HD nor have any studies addressed the treatment of psychiatric disturbances in ET. We conclude that there is the need of controlled studies to better evaluate pharmacological and non-pharmacological treatment of psychiatric disturbances in hyperkinetic movement disorders.

Keywords: Dystonia; Huntington disease; Tourette syndrome; anxiety; attention deficit hyperactivity disorder; depression; essential tremor; obsessive compulsive disorders; psychosis; tic.

Publication types

  • Review

MeSH terms

  • Anxiety Disorders / therapy*
  • Attention Deficit Disorder with Hyperactivity / therapy*
  • Depressive Disorder / therapy*
  • Dystonic Disorders / therapy*
  • Essential Tremor / therapy*
  • Humans
  • Huntington Disease / therapy*
  • Hyperkinesis / therapy*
  • Obsessive-Compulsive Disorder / therapy*
  • Tic Disorders / therapy*