Vertical Bone Regeneration with Synthetic Biomimetic Calcium Phosphate onto the Calvaria of Rats

Tissue Eng Part C Methods. 2019 Jan;25(1):1-11. doi: 10.1089/ten.TEC.2018.0260.


This work reports a new bone substitute made of precipitated apatite crystals that resemble in composition and crystallinity to the mineral phase of bone. The bone regeneration capacity of this synthetic biomimetic calcium phosphate (SBCP) was studied by using an original model of vertical bone regeneration with cups on the calvaria of rats. After 4 weeks, a significantly higher bone growth was found with SBCP compared with deproteinized bovine bone matrix and empty controls. This rapid vertical bone regeneration indicated that this new biomaterial is particularly interesting for filling bone defects in oral surgery.

Keywords: calvaria; cups; deproteinized bovine bone matrix; hydroxyapatite; rats; synthetic biomimetic calcium phosphate; vertical bone regeneration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biomimetics*
  • Bone Regeneration / drug effects*
  • Bone Substitutes / pharmacology*
  • Calcium Phosphates / pharmacology*
  • Male
  • Rats
  • Rats, Wistar
  • Skull / cytology*
  • Skull / drug effects
  • Skull / physiology


  • Bone Substitutes
  • Calcium Phosphates
  • calcium phosphate