Effects of 12-wk Lactobacillus plantarum OLL2712 treatment on glucose metabolism and chronic inflammation in prediabetic individuals: A single-arm pilot study

Nutrition. 2019 Feb;58:175-180. doi: 10.1016/j.nut.2018.07.116. Epub 2018 Aug 23.


Objective: Previously, we demonstrated that the administration of heat-killed OLL2712 cells suppressed chronic inflammation and improved hyperglycemia in a mouse model of obesity and diabetes. The aim of this study was to preliminarily examine the effect of OLL2712 supplementation on glucose metabolism and chronic inflammation in prediabetic subjects.

Methods: This study was a prospective, 12-wk, single-arm, open trial, followed by a 4-wk posttreatment period. Inclusion criteria were fasting plasma glucose levels of 105 to 130 mg/dL in an age range of 35 to 65 y. Thirty individuals consumed a dairy beverage containing ∼1 × 1010 heat-killed OLL2712 cells for 12 wk.

Results: The ingestion of the OLL2712 beverage significantly improved fasting plasma glucose levels, serum glycoalbumin levels, and insulin resistance indexes compared with baseline levels. The intervention also suppressed serum monocyte chemotactic protein-1 and interleukin-6 levels, which are proinflammatory cytokines involved in the development of insulin resistance and hyperglycemia. Furthermore, stratified analysis by these proinflammatory cytokine levels revealed that the beneficial effects of OLL2712 beverage were observed particularly in individuals with chronic inflammation at baseline.

Conclusion: The results of this study suggested that heat-killed OLL2712 cells have the potential to improve insulin resistance and glucose metabolism by suppressing chronic inflammation.

Keywords: Fasting plasma glucose; HOMA-IR; IL-6; Insulin resistance; MCP-1.

MeSH terms

  • Adult
  • Aged
  • Blood Glucose / drug effects
  • Blood Glucose / metabolism*
  • Chronic Disease
  • Female
  • Humans
  • Inflammation / blood
  • Inflammation / drug therapy*
  • Insulin Resistance
  • Lactobacillus plantarum*
  • Male
  • Middle Aged
  • Pilot Projects
  • Prediabetic State / blood
  • Prediabetic State / metabolism*
  • Probiotics / administration & dosage
  • Probiotics / pharmacology*
  • Prospective Studies
  • Serum Albumin / drug effects
  • Serum Albumin / metabolism
  • Treatment Outcome


  • Blood Glucose
  • Serum Albumin
  • glycosylated serum albumin