Geraniol Interferes With Membrane Functions in Strains of Candida and Saccharomyces

Lipids. 1988 Jun;23(6):534-8. doi: 10.1007/BF02535593.

Abstract

Geraniol, an olefinic terpene, was found to inhibit growth of Candida albicans and Saccharomyces cerevisiae strains. Geraniol was shown to enhance the rate of potassium leakage out of whole cells and also was shown by fluorescence polarization to increase C. albicans membrane fluidity. Biophysical studies using differential scanning calorimetry, fluorescence polarization and osmotic swelling of phospholipid vesicles demonstrated that geraniol decreased the phase-transition temperature of dipalmitoylphosphatidylcholine vesicles, affected fluidity throughout the bilayer, particularly the central portion of the bilayers, and caused an increase in bilayer permeability to erythritol. Geraniol may have potential use as an antifungal agent.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Acyclic Monoterpenes
  • Antifungal Agents*
  • Calorimetry, Differential Scanning
  • Candida albicans / drug effects*
  • Candida albicans / metabolism
  • Cell Membrane Permeability / drug effects
  • Erythritol / metabolism
  • Fluorescence Polarization
  • Liposomes / metabolism
  • Membrane Fluidity / drug effects*
  • Microbial Sensitivity Tests
  • Potassium / metabolism
  • Saccharomyces cerevisiae / drug effects*
  • Saccharomyces cerevisiae / metabolism
  • Terpenes / pharmacology*

Substances

  • Acyclic Monoterpenes
  • Antifungal Agents
  • Liposomes
  • Terpenes
  • geraniol
  • Erythritol
  • Potassium