Ascorbic acid derivative DDH-1 ameliorates psoriasis-like skin lesions in mice by suppressing inflammatory cytokine expression

J Pharmacol Sci. 2018 Dec;138(4):284-288. doi: 10.1016/j.jphs.2018.11.002. Epub 2018 Nov 20.

Abstract

Psoriasis is a chronic inflammatory skin disease in which inflammatory cytokines play a major role in its pathogenesis. Because DDH-1, a novel amphipathic ascorbic acid derivative, has been recently shown to reduce inflammatory cytokine expression in human keratinocytes in vitro, we investigated its effect on imiquimod-induced psoriasis-like skin lesions in C57BL/6 mice. We first found that IL-1β and TNF-α mRNA expression was significantly decreased in the skin lesions treated with DDH-1. Furthermore, cutaneous administration of DDH-1 ameliorated psoriasis-like skin lesions. These results suggest that DDH-1 may be effective in the prevention and supplemental treatment of psoriasis.

Keywords: Ascorbic acid derivative; Inflammatory cytokine; Psoriasis.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology
  • Anti-Inflammatory Agents / therapeutic use
  • Ascorbic Acid / analogs & derivatives*
  • Ascorbic Acid / pharmacology
  • Ascorbic Acid / therapeutic use*
  • Cytokines / genetics
  • Cytokines / immunology*
  • Female
  • Imiquimod
  • Mice, Inbred C57BL
  • Psoriasis / chemically induced
  • Psoriasis / drug therapy*
  • Psoriasis / immunology
  • Skin / drug effects
  • Skin / immunology

Substances

  • Anti-Inflammatory Agents
  • Cytokines
  • Imiquimod
  • Ascorbic Acid