S-adenosylmethionine in the treatment of depression

Neurosci Biobehav Rev. 1988 Summer;12(2):139-41. doi: 10.1016/s0149-7634(88)80005-8.


The antidepressant property of S-adenosylmethionine (SAMe) has been supported by several uncontrolled and controlled studies. Compared to standard antidepressant agents, SAMe has fewer side-effects and shorter lag period. Future studies to delineate SAMe-responsive depression are warranted.

Publication types

  • Clinical Trial
  • Review

MeSH terms

  • Clinical Trials as Topic
  • Depressive Disorder / drug therapy*
  • Humans
  • S-Adenosylmethionine / therapeutic use*


  • S-Adenosylmethionine