Chemical Synthesis of Glycosides of N-Acetylneuraminic Acid

Cristina De Meo; Bradley T Jones

doi:10.1016/bs.accb.2018.09.005

Chemical Synthesis of Glycosides of N-Acetylneuraminic Acid

Adv Carbohydr Chem Biochem. 2018:75:215-316. doi: 10.1016/bs.accb.2018.09.005. Epub 2018 Nov 23.

Authors

Cristina De Meo¹, Bradley T Jones²

Affiliations

¹ Department of Chemistry, Southern Illinois University-Edwardsville, Edwardsville, IL, United States. Electronic address: cdemes@siue.edu.
² Department of Chemistry, Southern Illinois University-Edwardsville, Edwardsville, IL, United States.

PMID: 30509401
DOI: 10.1016/bs.accb.2018.09.005

Abstract

Investigations of methodologies aimed on improving the stereoselective synthesis of sialosides and the efficient assembly of sialic acid glycoconjugates has been the mission of dedicated research groups from the late 1960s. This review presents major accomplishments in the field, with the emphasis on significant breakthroughs and influential synthetic strategies of the last decade.

Keywords: Chemical synthesis; Glycoconjugates; N-Acetylneuraminic acid; Neuraminic acid; Sialic acid.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Carbohydrate Conformation
Glycosides / chemical synthesis*
Glycosides / chemistry
N-Acetylneuraminic Acid / chemistry*

Substances

Glycosides
N-Acetylneuraminic Acid