Inhibition of B-cell function by concanavalin-A-induced suppressor cells

Scand J Immunol. 1977;6(12):1329-32. doi: 10.1111/j.1365-3083.1977.tb00373.x.

Abstract

The in vitro immune response of normal spleen cells to the thymus-independent antigen dinitrophenylated levan (DNP-LE) was found to be inhibited by suppressor cells induced previously by concanavalin A (Con A) in vitro. At various suppressor to target cell ratios, the level of suppression observed was comparable to that seen in anti-sheep erythrocyte (SRBC) responses. Consequently, it is suggested that B cells constitute a direct target for Con-A-induced suppressor cell activity.

MeSH terms

  • Animals
  • Antibody Formation
  • B-Lymphocytes / immunology*
  • Concanavalin A / pharmacology*
  • Dinitrobenzenes / immunology
  • Erythrocytes / immunology
  • Immunosuppression Therapy*
  • Mice
  • Mice, Inbred CBA
  • Sheep
  • Spleen / immunology

Substances

  • Dinitrobenzenes
  • Concanavalin A