Orchestrating Nuclear Envelope Sealing during Mitosis

Marina Vietri; Harald Stenmark

doi:10.1016/j.devcel.2018.11.020

Orchestrating Nuclear Envelope Sealing during Mitosis

Dev Cell. 2018 Dec 3;47(5):541-542. doi: 10.1016/j.devcel.2018.11.020.

Authors

Marina Vietri¹, Harald Stenmark²

Affiliations

¹ Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Montebello, N-0379 Oslo, Norway; Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, N-0379 Oslo, Norway.
² Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Montebello, N-0379 Oslo, Norway; Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, N-0379 Oslo, Norway. Electronic address: stenmark@ulrik.uio.no.

PMID: 30513298
DOI: 10.1016/j.devcel.2018.11.020

Abstract

Sealing of the nascent nuclear envelope during mitotic exit is mediated by the polymeric ESCRT-III protein machinery. In this issue of Developmental Cell, Ventimiglia et al. (2018) identify the ESCRT-III-associated protein CC2D1B as a lipid-binding coordinator of late-mitotic ESCRT-III assembly and disassembly of the mitotic spindle.

Publication types

Comment

MeSH terms

Endosomal Sorting Complexes Required for Transport / genetics*
Mitosis
Nuclear Envelope*
Spindle Apparatus

Substances

Endosomal Sorting Complexes Required for Transport