A division of labor in mTORC1 signaling and autophagy

Sci Signal. 2018 Dec 4;11(559):eaav3530. doi: 10.1126/scisignal.aav3530.

Abstract

In human cells, the p62 protein acts as an adaptor in various signaling pathways as well as a receptor for selective autophagy. In this issue of Science Signaling, Sanchez-Garrido et al show that proteolytic cleavage of p62 by caspase-8 determines whether p62 functions as an mTORC1 signaling adaptor or autophagy receptor.

Publication types

  • Review
  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Autophagy*
  • Humans
  • Mechanistic Target of Rapamycin Complex 1
  • Nutrients
  • Proteolysis
  • Sequestosome-1 Protein

Substances

  • Adaptor Proteins, Signal Transducing
  • SQSTM1 protein, human
  • Sequestosome-1 Protein
  • Mechanistic Target of Rapamycin Complex 1