Canary in the Coal Mine? Transmitted Mutations Conferring Resistance to All Integrase Strand Transfer Inhibitors in a Treatment-Naive Patient

Open Forum Infect Dis. 2018 Nov 8;5(11):ofy294. doi: 10.1093/ofid/ofy294. eCollection 2018 Nov.


Transmitted drug resistance to the integrase strand transfer inhibitor (INSTI) class of antiretrovirals is very rare. We present a case of a treatment-naive female patient with human immunodeficiency virus harboring resistance to all INSTIs, including bictegravir and dolutegravir.

Keywords: HIV; integrase; transmitted resistance; treatment naive.