Afamelanotide in the Treatment of Dermatologic Disease

Skin Therapy Lett. 2018 Nov;23(6):6-10.


Afamelanotide, an α-melanocyte stimulating hormone analogue, has become an emerging therapeutic option for a variety of skin conditions previously refractory to other treatments. Its efficacy has been demonstrated in several dermatologic conditions, including erythropoietic protoporphyria (EPP), solar urticaria, polymorphic light eruption (PMLE), vitiligo, acne, and Hailey-Hailey disease. Its relatively low risk side effect profile makes it an attractive treatment option and also paves the way for innovative use in other disorders.

Keywords: acne; afamelanotide; alpha-melanocyte stimulating hormone; erythropoietic protoporphyria; Hailey-Hailey disease; polymorphic light eruption; solar urticaria; vitiligo.