Sleep deprivation alters the time course but not magnitude of locomotor sensitization to cocaine

Sci Rep. 2018 Dec 5;8(1):17672. doi: 10.1038/s41598-018-36002-1.


Repeated exposure to drugs of abuse progressively increases the response to the same stimuli, a process known as sensitization. Behavioral sensitization to cocaine administration is often measured in non-human subjects via locomotor activity which is easily quantifiable. The effects of four hours of sleep deprivation on repeated cocaine (five daily and one challenge) showed attenuated hyperactivity on the first day only, compared to the non-deprived group. Both groups reached the same final level of sensitization, indicating that sleep deprivation altered the time course, but not magnitude of locomotor sensitization.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Cocaine / administration & dosage
  • Cocaine / pharmacology*
  • Cocaine-Related Disorders / complications*
  • Cocaine-Related Disorders / physiopathology
  • Dopamine Uptake Inhibitors / administration & dosage
  • Dopamine Uptake Inhibitors / pharmacology*
  • Locomotion / drug effects*
  • Male
  • Mice, Inbred C57BL
  • Sleep Deprivation / complications*
  • Sleep Deprivation / physiopathology


  • Dopamine Uptake Inhibitors
  • Cocaine