The effectiveness of topical therapy combined with 308-nm excimer laser on vitiligo compared to excimer laser monotherapy in pediatric patients

Pediatr Dermatol. 2019 Jan;36(1):e53-e55. doi: 10.1111/pde.13726. Epub 2018 Dec 5.

Abstract

We evaluated the efficiency of using a 308-nm excimer laser with either tacrolimus, pimecrolimus, or halometasone for the treatment of childhood vitiligo. Patients who received combined treatments had significantly higher rates of repigmentation in comparison with individuals who underwent excimer laser alone therapy. Moreover, patients who received treatment with excimer laser and halometasone had significantly higher rates of repigmentation, even higher than individuals who were treated with tacrolimus combined or pimecrolimus combined. This regimen was more effective on the face, neck, and limbs. We conclude that the use of a combined excimer laser and halometasone cream has a greater therapeutic effect than laser alone.

Keywords: 308-nm excimer laser; halometasone; pimecrolimus; tacrolimus; vitiligo.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Administration, Topical
  • Betamethasone / administration & dosage
  • Betamethasone / analogs & derivatives*
  • Child
  • Combined Modality Therapy
  • Dermatologic Agents / therapeutic use*
  • Humans
  • Lasers, Excimer / therapeutic use*
  • Prospective Studies
  • Skin Pigmentation / drug effects
  • Tacrolimus / administration & dosage*
  • Tacrolimus / analogs & derivatives*
  • Treatment Outcome
  • Vitiligo / therapy*

Substances

  • Dermatologic Agents
  • pimecrolimus
  • Betamethasone
  • halometasone
  • Tacrolimus